RELATIONSHIP OF THE METABOLIC SYNDROME AND CORONARY ARTERY DISEASE IN PATIENTS WITH STABLE ANGINA

Abstract

Abstract
INTRODUCTION: In view of the high prevalence of coronary artery diseases (CAD)
and the fact that the metabolic syndrome is known to predispose to CAD, we studied the
relationship between various components of the metabolic syndrome and the severity of
CAD.
METHODS: A total of 545 patients with stable angina were included in this crosssectional
study. Questionnaires were used to obtain information on demographic
characteristics, drug history, and history of previous hospitalization. Blood pressure (BP)
and waist circumference (WC) were measured. Ten-hour fasting blood samples were
taken to measure blood sugar, high-density lipoprotein cholesterol (HDL-C), and
triglyceride (TG) using autoanalyzer. Angiography was performed with the standard
method and the patients were scored using extent scoring. The metabolic syndrome was
defined according to ATP-III. SPSS 11 was use to analyze data with t-test, ANOVA,
correlation and logistic regression tests.
RESULTS: The patients had a mean age of 57.93±10.13 years. High HDL-C was the
most frequent abnormality, followed by increased WC and TG. Severity of metabolic
syndrome increased with age. CAD was detected in 78.9% of patients with the metabolic
syndrome and 46.7% of patients without it (P<0.05). In regression analysis, the
metabolic syndrome was found to be a risk factor for CAD (OR=1.35, CI=1.13-1.60).
Direct correlation was found between angiography score and metabolic syndrome
(P<0.01, r=0.15).
CONCLUSIONS: The metabolic syndrome is a predisposing factor to CAD; hence CAD
prevention should involve measures to control metabolic syndrome, especially through
lifestyle modification.
Key Words: Metabolic syndrome, CAD.