CORRELATION BETWEEN BODY FAT DISTRIBUTION, PLASMA LIPIDS AND APOLIPOPROTEINS WITH THE SEVERITY OF CORONARY IN-VOLVEMENT IN PATIENTS WITH STABLE ANGINA

Abstract

BACKGROUND: Previous studies reported that the distribution of body fat is an important risk factor for coronary artery diseases (CAD) and abdominal adipose tissue is associated with severe CAD. This study was conducted to evaluate the relationship between body fat distributions, plasma lipids and the severity of CAD in patients with stable angina.

   METHODS: Ninety seven patients who underwent coronary angiography for stable angina were allocated into two groups: patients with mild or sever coronary artery involvement. Lipid profile (total cholesterol, LDL, HDL) and triglyceride (TG) and apolipoprotein A and B, were measured for all of the participants and a demographic data questionnaire was filled by the subjects. Participants underwent abdominal computed tomography (CT-Scan) for measurement of adipose tissues that was classified to visceral and superficial and deep subcutaneous fat tissue compartment.

   RESULTS: Patients with severe coronary artery involvement had higher level of apo B
(P = 0.02). Significant correlation was seen between visceral fat index and TG (P = 0.01), HDL-C (P < 0.01) in patients with mild coronary involvement and with total cholesterol (P = 0.02), LDL-C (P = 0.01) and apoB (P < 0.01) in patients with severe coronary involvement .No significant relationship was seen among deep cutaneous fat index and lipid profile in both groups.

   CONCLUSION: Our findings showed that visceral adipose tissue is significantly associated with severe CAD and has a significant correlation with lipid profile as well as Apo B.

Keywords: Visceral Abdominal Adipose Tissue, Superficial Subcutaneous Adipose Tissue, Deep Subcutaneous Adipose Tissue, Coronary Involvement, Lipid Profile.