ASSESSMENT OF ANTIOXIDANT NUTRIENT INTAKE AND  MALONDIADEHYDE PLASMA LEVEL IN RHEUMATOID ARTHRITIS

Yousef Shaabani; Maryam Foroughi; Reza Rastmanesh; Ahmadreza Jamshidi; Narges Tajik; Omid Assadi

Spring 2009

ASSESSMENT OF ANTIOXIDANT NUTRIENT INTAKE AND MALONDIADEHYDE PLASMA LEVEL IN RHEUMATOID ARTHRITIS

Yousef Shaabani, Maryam Foroughi, Reza Rastmanesh, Ahmadreza Jamshidi, Narges Tajik, Omid Assadi

Abstract

Abstract

BACKGROUND: Elevated free radical generation in inflamed jointsand impaired antioxidant systems have been implicated in rheumatoidarthritis (RA). The present study was performed to evaluatedietary nutrient intake and plasma oxidant statusin RA patients.

METHODS: This case-control study comprised 75 RA patients and equal number of age- and gender-matchedcontrols. Nutrient intake was estimated by using a semi-quantitativefood frequency questionnaire. Blood sampleswere obtained from each group, and as an indicator of oxidant status, plasma concentrations of malondiadehyde (MDA) were measured.

RESULTS: The mean calorie intake of RA patients was lower thanthat of the healthy controls. Energy-adjusted intake of fat,vitamin A and ß-carotene were significantly lowerin patients than in control .Plasma MDA concentration was significantly higher in RA patients than in controls (4.9±1.8 vs 2.1±0.6 nmoles/ml respectively, P < 0.01).

CONCLUSION: These results suggest proper antioxidant nutrientintake management may reduce free radical generation and improveantioxidant status in RA patients.

Keywords: rheumatoid arthritis, antioxidant, malondialdehyde.

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