IL-4 AND INTERFERON GAMMA IN RECENTLY DIAGNOSED  TYPE I DIABETES, A CASE-CONTROL STUDY

Mohammad Hassan Khazai; Jalil Tavakkol Afshari; Bahram Khazai; Javad Akbarzadeh; Ladan Khazai; Mohammad Reza Abbaszadegan; Farhad Khadivizand

Spring 2007

IL-4 AND INTERFERON GAMMA IN RECENTLY DIAGNOSED TYPE I DIABETES, A CASE-CONTROL STUDY

Mohammad Hassan Khazai, Jalil Tavakkol Afshari, Bahram Khazai, Javad Akbarzadeh, Ladan Khazai, Mohammad Reza Abbaszadegan, Farhad Khadivizand

Abstract

Abstract

INTRODUCTION: The aim of this study was to measure serum levels of interferon-gamma (IFN-γ) and interleukin-4 (IL-4), the two major cytokines secreted by Th-1 and Th-2 cells, in islet cell autoantibody (ICA)-positive, newly-diagnosed type I diabetic patients.

methods: The study was conducted on 30 newly diagnosed, ICA-positive type I diabetics and 30 age- and sex-matched healthy controls. Cytokine levels in serum were quantified by indirect sandwich ELISA in pg/ml.

results: We observed no significant difference in concentration of IL-4 in ICA-positive diabetics (median=126.535) compared with healthy controls (median=136.440) (P>0.05). IFN-γ levels were significantly higher in patients (median=11.305) compared with healthy controls (median=8.200) (P<0.05).

CONCLUSIONS: Increased levels of IFN-γ in patients may be suggestive of its destructive role in the pathophysiology of type I autoimmune diabetes.

Keywords: Type I diabetes mellitus, interleukin-4 (IL-4), interferon-gamma (IFN-γ), islet cell autoantibody (ICA), T-helper 1 (Th-1) response, T-helper 2 (Th-2

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