ARYA Atherosclerosis7119700101Systemic thrombolysis in the upper extremity deep vein thrombosis245245ENRoxanaSadeghiAssistant Professor of Cardiology, Cardiovascular Research Center, Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences (SUMS), Tehran. roxan.sadeghi@gmail.comMortezaSafi20110503Almost 4% of all patients with venous thrombosis have upper extremity deep vein thrombosis(UEDVT) and the incidence of UEDVT increases over time. The frequency of post-thromboticsyndrome (PTS) after UEDVT is not low and upper extremity PTS is a potentially majormorbidity that adversely affects quality of life, particularly if the dominant arm is involved. Wediscuss briefly the role of thrombolytic therapy in the treatment of upper extremity deep veinthrombosis and also the role of systemic thrombolysis in selected patients.Keywords: Venous Thrombosis, Post-thrombotic Syndrome, Upper Extremity Deep VeinThrombosis, Paget-Schroetter Syndrome, Effort Induced Upper Extremity Deep Vein Thrombosis,Central Venous Catheter Thrombosis, Thoracic Outlet Syndrome, Axillary Vein, Subclavian Vein.