ARYA Atherosclerosis7420120102Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits271271ENSedigheAsgarySomayehNajafiMSc, Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.. s.najafi.bio@gmail.comAlirezaGhannadiGholamrezaDashtiAlirezaHelalat2011091920111108BACKGROUND: Hypercholesterolemia is among the most common health problems treated withtraditional remedies. Nigella sativa (NS) is an effective plant for treating hypercholesterolemia.However, the effects of this herb on hematologic factors and hemostasis system have not beenelucidated. This study was designed to investigate the effects of NS on these factors in bothnormal and hypercholesterolemic rabbits.METHODS: In this research, twenty rabbits were randomly distributed into four groups of five. Thegroups received four different diets, namely normal, normal + NS (5%), hypercholesterolemic (1٪cholesterol), and hypercholesterolemic (1٪ cholesterol) + NS (5%), for 8 weeks. After this period,WBC (white blood cell), RBC (red blood cell), HTC (hematocrit), HGB (hemoglobin content), PLT(platelet), fibrinogen (FIB) and factors VII (F VII) were measured.RESULTS: Using NS significantly increased PLT count in the normal group. In addition, it significantlydecreased WBC counts in the hypercholesterolemic group (P < 0.05). However, dietaryuse of NS did not have any effects on other hematologic factors including RBC, HTC, HGB, FIB,and F VII (P < 0.05).CONCLUSION: Increased PLT numbers might cause enhanced coagulation. The achieved resultscall for more research on the effects of various diets (hypercholesterolemic and normal diet)supplemented with NS on different coagulation factors and hemostasis system.Keywords: Hematological Factors, Hypercholesterolemia, Nigella Sativa L., Rabbit.