RELATIONSHIPS OF SERUM LEPTIN CONCENTRATION WITH   INSULIN, GLUCOSE, HbA1c LEVELS AND INSULIN RESISTANCE  IN OVERWEIGHT POST-MENOPAUSAL DIABETIC WOMEN

Maryam Taghdir; Abolghasem Djazayeri; Mahmoud Djalali; Mohammadreza Eshraghian; Asadollah Rajab; Haleh Sadrzade Yegane; Mahkameh Ashourpour; Mojtaba Sepandi

Winter 2010

RELATIONSHIPS OF SERUM LEPTIN CONCENTRATION WITH INSULIN, GLUCOSE, HbA1c LEVELS AND INSULIN RESISTANCE IN OVERWEIGHT POST-MENOPAUSAL DIABETIC WOMEN

Maryam Taghdir, Abolghasem Djazayeri, Mahmoud Djalali, Mohammadreza Eshraghian, Asadollah Rajab, Haleh Sadrzade Yegane, Mahkameh Ashourpour, Mojtaba Sepandi

Abstract

Abstract

BACKGROUND: Leptin, the product of the ob gene, could have a role in the pathogenesis of obesity and non-insulin dependent diabetes mellitus (NIDDM). The aim of this study was to investigate relationships between serum leptin concentration and insulin, glucose, HbA1c levels and insulin resistance in diabetic women.

METHODS: We studied 45 diabetic women and 45 healthy women (controls) who aged 45-60 years and had BMI of 25-30 kg/m². Serum leptin, insulin, HbA1c, fasting blood sugar and insulin resistance were determined in the two groups.

RESULTS: There was a significant positive correlation between leptin and insulin (r = 0.295, P = 0.049) and insulin resistance (r = 0.329, P = 0.027) in controls but non-significant correlation between leptin and HbA1c and fasting blood sugar were observed in the two groups.

CONCLUSION: This study did not document any significant relationship between serum leptin and insulin, glucose, HbA1c and insulin resistance in diabetic women.

Keywords: Type 2 Diabetes Mellitus, Leptin, Insulin.

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