ARYA Atherosclerosis5420101130RELATIONSHIPS OF SERUM LEPTIN CONCENTRATION WITH INSULIN, GLUCOSE, HbA1c LEVELS AND INSULIN RESISTANCE IN OVERWEIGHT POST-MENOPAUSAL DIABETIC WOMEN2929ENMaryamTaghdirAbolghasemDjazayeriPhD, Professor of Nutrition, Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sciences, Tehran.. jazaiers@tums.ac.irMahmoudDjalaliMohammadrezaEshraghianAsadollahRajabHalehSadrzade YeganeMahkamehAshourpourMojtabaSepandi20101129Abstract    BACKGROUND: Leptin, the product of the ob gene, could have a role in the pathogenesis of obesity and non-insulin dependent diabetes mellitus (NIDDM). The aim of this study was to investigate relationships between serum leptin concentration and insulin, glucose, HbA1c levels and insulin resistance in diabetic women.    METHODS: We studied 45 diabetic women and 45 healthy women (controls) who aged 45-60 years and had BMI of 25-30 kg/m2. Serum leptin, insulin, HbA1c, fasting blood sugar and insulin resistance were determined in the two groups.    RESULTS: There was a significant positive correlation between leptin and insulin (r = 0.295, P = 0.049) and insulin resistance (r = 0.329, P = 0.027) in controls but non-significant correlation between leptin and HbA1c and fasting blood sugar were observed in the two groups.    CONCLUSION: This study did not document any significant relationship between serum leptin and insulin, glucose, HbA1c and insulin resistance in diabetic women.      Keywords: Type 2 Diabetes Mellitus, Leptin, Insulin.