ARYA Atherosclerosis7520120313Evaluation of early alterations in transmitral diastolic flow and tissue doppler imaging findings of the septal and lateral segments of the left ventricle in the early period after coronary angioplasty388388ENHasanShemiraniKajhalKarimiResident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.. pathosafar@yahoo.comRezaMadadi20120313BACKGROUND: We aimed to evaluate subepicardial and subendocardial left ventricular (LV)functions in patients with single coronary artery lesion at an early stage after percutaneouscoronary intervention (PCI).METHODS: Patients with left anterior descending (LAD) lesion (n = 40) were evaluated.Subjects underwent PCI and at least one coronary stent was placed. Before and one month afterPCI, patients underwent echocardiography. The ordinary Doppler indicators including E wavedeceleration time, A velocity and E velocity as well as the pulsed-wave tissue Doppler imaging(PW-TDI) parameters (Aa, Ea and Sa velocity) were measured. The findings before and afterintervention were compared.RESULTS: E wave deceleration time was the only factor that significantly improved in ordinaryDoppler and other parameters such as A velocity and E velocity did not show any changes.Among TDI parameters, Aa velocity and Ea velocity in septum area improved significantly butdespite an increase in Sa velocity in septum, it was not statistically significant. Ea velocitysignificantly improved in lateral area but Aa and Sa velocity insignificantly increased.CONCLUSION: In patients with coronary artery disease, the systolic and diastolic function isimpaired. It is simply diagnosable by TDI. Although the systolic function impairment isremained after PCI, the diastolic function considerable improved after angioplasty. Our studyshowed that diastolic function of left ventricle improved over time. In contrast with otherstudies, in this study, Aa velocity significantly improved one month after revascularization.Keywords: Angioplasty, Percutaneous Coronary, Echocardiography, Doppler, Tissue Doppler